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KMID : 0903520090520050486
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2009 Volume.52 No. 5 p.486 ~ p.492
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Rhodiosin, an Antioxidant Flavonol Glycoside from Rhodiola rosea
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Kwon Hyung-Jun
Ryu Young-Bae
Jeong Hyung-Jae
Kim Jang-Hoon
Park Su-Jin
Chang Jong-Sun
Kim Min-Soo
Rho Mun-Chual
Lee Woo-Song
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Abstract
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The EtOAc fraction of Rhodiola rosea ethanolic extracts showed a strong antioxidant activity. Through activity-guided fractionation and purification, we isolated two flavonol glycosides, which were identified as the well known flavonoids, rhodionin (1) and rhodiosin (2). To compare their antioxidant activities, we used an authentic aglycone compound, herbacetin (3). Among the compounds tested, rhodiosin (2) exhibited strong antioxidant activity, with IC50 values of 0.21 and 0.15 μM against ·OH and ·O-2, respectively. Rhodiosin (2) (100 mg/kg) reduced MDA content in the liver induced by irradiation when given prior to exposure of γ-radiation.
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KEYWORD
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antioxidant, γ-irradiation, Rhodiola rosea, rhodiosin, UWLA
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